Anion Exchangers
Anion Exchangers
Anion Exchangers are a critical class of transmembrane proteins that primarily facilitate the exchange of anions, such as Cl-, HCO3-, and SO22-, between the intracellular and extracellular environment through the antiport mechanism. Anion Exchangers mainly include members of the solute carrier 4 (SLC4) and solute carrier 26 (SLC26) families, such as AE1 (SLC4A1), AE2 (SLC4A2), AE3 (SLC4A3), DRA (SLC26A3), and PAT1 (SLC26A6), which are widely distributed in tissues such as red blood cells, kidneys, and the digestive tract.
Anion Exchangers play a pivotal role in physiological processes such as maintaining acid-base balance, ion homeostasis, and metabolite excretion. Dysfunction of these proteins is closely associated with various diseases, including hereditary distal renal tubular acidosis, metabolic disorders, and abnormal regulation of the tumor microenvironment[1][2].
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Anion Exchangers Related Products (7)
Related Products (7)
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Xipamide
0 ImagesXipamide is an orally active carbonic anhydrase (CA) inhibitor and Na+/Cl--potassium transporter inhibitor with diuretic and antihypertensive effects. Xipamide reduces NaCl reabsorption by inhibiting the Cl-/NaCO3- anion exchanger, and increases calcium reabsorption while promoting potassium and magnesium excretion. Xipamide is mainly cleared via the renal pathway and causes a temporary decrease in glomerular filtration rate under specific conditions. Xipamide does not affect Ca2+ signaling induced by endothelin-1 and other factors, nor does it inhibit various ion cotransport or pump activities in red blood cells. Xipamide can be used in researches related to cardiovascular diseases, hypertension (especially with left ventricular hypertrophy), advanced renal failure, and liver cirrhosis with ascites.
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OB-1
0 ImagesOB-1 is a stomatin-like protein-3 (STOML3) oligomerization blocker. OB-1 is an effective inhibitor of the self-association of Stomatin, STOML1 and STOML2, but not podocin.
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DEAE Cross-linked dextran A 25
0 ImagesCat. No.: HY-103703CAS No.: 12609-80-2DEAE Cross-linked dextran A 25 is a weak anion exchange chromatography packing material. DEAE Cross-linked dextran A 25 can be used for the analysis of trace metal humic acid complexes in river water and the purification of biomacromolecules. DEAE Cross-linked dextran A 25 can also be used for research on diseases related to abnormal AVP levels.
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Anion transporter-4
0 ImagesCat. No.: HY-174148Anion transporter-4 (Compound 6) is a small-molecule anion transporter, which induces tubulin degradation and mitochondrial dysfunction. Anion transporter-4 can increase intracellular anion levels such as chloride ions by disrupting microtubule dynamics, promoting lipid peroxidation, and impairing mitochondrial function. Anion transporter-4 triggers ferroptosis to exert anticancer activity. Anion transporter-4 is promising for research of cancers.
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AST 7062601
0 ImagesCat. No.: HY-153812CAS No.: 675197-89-4Synonyms: AST070AST 7062601 (AST070) is a Ucp1 inducer that strongly induces endogenous Ucp1 expression in primary mouse brown adipocytes. Ucp1 refers to uncoupling protein, found in brown and beige fat cells. In mammals, UCP1 oxidizes fatty acids and uncouples ATP production in mitochondria to promote energy dissipation as heat. AST 7062601 can be used to study thermogenic, uncoupled respiration.
